Curriculum Philippe Conus

Service de Psychiatrie Générale Département de Psychiatrie CHUV Clinique de Cery 1008 Prilly Schweiz Tél.: +41 21 643 61 11 Fax: +41 21 643 64 69 E-Mail

Biographie professionnelle:

Champ d’action actuel:
Psychiatrie générale adulte, Intervention précoce dans les troubles psychotiques

Lieu de travail actuel:
Service de Psychiatrie Générale, Département de Psychiatrie CHUV, Clinique de Cery, 1008 Prilly

Priorité:
Conduite du service, enseignement, recherche, travail clinique

Publications:
(peer review au cours des 5 dernière années)

Henry LP, Harris MG, Amminger PG, Yuen HP, Harrigan SM, Lambert M, Conus P, Schwartz O, Prosser A, Farrelly S, Purcell R, Herrman H, Jackson HJ, McGprry PD. Early Psychosis Prevention and intervention Centre long-term follow-up study of first episode psychosis: methodology and baseline characteristics. Early Intervention in Psychiatry 2007; 1:49-60.

Conus P, Cotton S, Schimmelmann BG, McGorry PD, Lambert M. The First Episode Psychosis Outcome Study (FEPOS): Pre-morbid and baseline characteristics of 704 first episode psychosis patients treated in EPPIC between 1998 and 2000. Early Intervention in Psychiatry 2007; 1:191-200.

Conus P, Schimmelmann BG, Cotton S, McGorry PD, Lambert M. Pretreatment, baseline and outcome differences between early-onset and adult-onset psychosis in an epidemiological cohort of 636 first-episode patients. Schizophrenia Research 2007; 95:1-8.

Gysin R, Kraftsik R, Sandell J, Bovet P, Chappuis C, Conus P, Deppen P, Preisig M, Ruiz V, Tosic M, Werge T, Cuénod M, Do KQ. Redox dysregulation in schizophrenia: Convergent genetic and functional evidence for impaired glutathione synthesis. PNAS 2007; 104(42):16621-16626.

Berk M, Hallam K, Lucas N, Hasty M, Macneil C,  Conus P, Kader L, McGorry PD.  Early Intervention in Bipolar Disorders: Opportunities and Pitfalls. Medical Journal of Australia 2007; 187:S11-S14

Berk M, Conus P, Lucas N, Hallam K, Mahli GS, Dodd S, Yung AR, McGorry PD. Setting the stage: From prodrome to treatment resistance in bipolar disorder. Bipolar Disorders 2007; 9:671-678

Bonsack C, Montagrin Y, Favrod J, Gibellini S, Conus P. Une intervention motivationnelle pour les consommateurs de cannabis souffrant de psychose. Encéphale 2007 ; 33 :819-826

Lavoie S, Murray MM, Deppen P, Knyazeva MG, Berk M, Boulat O, Bovet P, Conus P, Copolov D, Cuenod M, Meuli R, Solida A, Buclin T, Do KQ. Glutathione precursor, N-Acetyl-Cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology 2008; 33:2187-99

Schimmelmann BG, Lambert M, Cotton S, McGorry PD, Conus P. Impact of duration of untreated psychosis in an epidemiological first-episode psychosis cohort. Journal of Psychiatric Research, 2008; 42:982-990.

Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I,  Hunt MA, Judd F, Katz F, Katz P, Jespersen S, Little J, Do KQ, Conus P, Bush AI. N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia: A Double Blind Randomised Placebo Controlled Trial. Biological Psychiatry 2008; 64, 361-368

Conus P, Berger G, Theodoridou A, Schneider R, Umbricht D, Michaelis-Conus K, Simon AE. Early intervention in bipolar disorders. Swiss Medical Forum 2008; 8(17):316-319.

Conus P, Ward J, Hallam KT, Lucas N, Macneil C, McGorry PD, Berk M. The proximal prodrome to first episode mania – a new target for early intervention. Bipolar Disorders 2008; 10:555-565

Morley KI, Cotton SM, Conus P, Lambert M, Schimmelmann BG, McGorry PD & Foley DL.  Familial psychopathology in the First Episode Psychosis Outcome Study.  Australian and New Zealand Journal of Psychiatry 2008; 42:617-626

Bonsack C, Montagrin Y, Gibellini S, Favrod J, Besson J, Conus P. Pratique d’une intervention motivationnelle pour les consommateurs de cannabis souffrant de psychose. Schweizer Archiv für Neurologie und Psychiatrie. 2008;159(6):378-85.

Robinson J, Cotton S, Conus P, Schimmelmann BG, McGorry PD, Lambert M. Prevalence and predictors of suicide attempt in an incidence cohort of 661 young people with first-episode psychosis. Australian and New Zealand Journal of Psychiatry 2009;43(2):149-157.

Cocchi L, Debanné M, Vianin P, Bircher R, Roulin S, Conus P, Sarrasin-Bruchez P, Bovet P, Volken H, Wood SJ, Schenk F. Encoding dysfunction in a dynamic-static paradigm for visuospatial working memory in frist-episode psychosis patients: 2-year follow-up study. Early Intervention in Psychiatry 2009; 3:44-51

Conus P, Cotton S, Schimmelmann BG, McGorry PD, Lambert M. Pre-treatment and outcome correlates of sexual and physical trauma in an epidemiological cohort of  first episode psychosis patients. Schizophrenia Bulletin, 2009 Apr 21, Epub ahead of print

Cocchi L, Bosisio F, Wood SJ, Berchtold A, Conus P, Orita A, Debanné M, Schenk F. Deficit dissociation between visuospatial working memory and visual pursuit processes in schizophrenia. Australian and New Zealand Journal of Psychiatry 2009 Aug;43(8):766-74.

Polari A, Macneil C, Berk M, Conus P. Duration of untreated psychosis – what are we talking about? Acta Neuropsychiatrica  2009;3:106-108.

Conus P, Berk M, Schäfer I. Trauma and psychosis: some aspects of a complex relationship. Acta Neuropsychiatrica 2009; 3:148-150.

Phillips LJ, Nelson B, Yuen HP, Francey SM, Simmons M, Stanford C, Ross M, Kelly D, Baker K, Conus P, Amminger P, Trumpler F, Yun Y, Lim M, McNab C, Yung AR, McGorry PD. Randomised controlled trial for interventions for young people at UHR of psychosis: Part 1: Study design and baseline characteristics. Australian and New Zealand Journal of Psychiatry 2009; 43:818-829

Cotton SM, Lambert M, Schimmelmann BG, Foley DL, Morley KI, McGorry PD, Conus P. Gender differences in premorbid, entry, trweatment and outcome characteristics in an epidemiological sample of 661 patients with first episode psychosis. Schizophrenia Research 2009 Jul 25. [Epub ahead of print]

Berk M, Berk L, Hasty M, Daglas R, Henry L, Conus P. Bipolar disorder: focus on maintenance. Medicine Today 2009; 10:25-32.

Macneil CA, Hasty MK, Conus P, Berk M. Termination of therapy: what can clinicians do to maximise gains? Acta Neuropsychiatrica 2010; 22:43-45.

Conus P, Ward J, Lucas N, Macneil C, Yung AR, Cotton S, Berk M, McGorry PD. Characterisation of the prodrome to a first episode of psychotic mania: results of a retrospective study. Journal of Affective Disorders, 2010 Jan 18. [Epub ahead of print]

Conus P, Lambert M, Cotton S, Bonsack C, McGorry PD, Schimmelmann BG. Rate and predictors of service disengagement in an epidemiological first-episode psychosis cohort. Schizophrenia Research. 2010 Mar 3. [Epub ahead of print]

Conus P, Cotton S, Schimmelmann BG, Berk M, Daglas R, McGorry PD, Lambert M. Pre-treatment and outcome correlates of past sexual and physical trauma in 118 bipolar I patients with a first episode of psychotic mania. Bipolar Disorders 2010; 12:244-252

Do KQ, Conus P, Cuenod M. Redox dysregulation and oxidative stress in schizophrenia: nutrigenetics as a challenge in psychiatric disease prevention. World Rev Nutr Diet. 2010;101:131-53

Conus P, Abdel-Baki A, Harrigan S, Lambert M, McGorry PD, Berk M. Pre-morbid and outcome correlates of first episode mania with psychotic features: is a distinction between schizoaffective and bipolar disorder valid in the early phase of psychotic disorders? J Affect Disord. 2010 Apr 28. [Epub ahead of print]

Robinson J, Harris M, Cotton S, Hughes A, Conus P, Lambert M, McGorry PD. Sudden death among young people with first episode psychosis: an 8 – 10 year follow-up. Psychiatry Research. 2010 May 30;177(3):305-308.

Bechdolf A, Nelson B, Thompson A, Cotton SM, Chanen A, Kettle J, Conus P, Amminger GP, Yung AR, McGorry PD. A preliminary evaluation of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults. Journal of Affective Disorders 2010 127(1-3):316-320. Epub 2010 Jul 8.

Yücel M, Bora E, Lubman DI, Solowij N, Brewer WJ, Cotton SM, Conus P, Takagi MJ, Fornito A, Wood SJ, McGorry PD, Pantelis C. The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first episode sample. Schizophrenia Bulletin 2010 Jul 25 [Epub ahead of print]

Gysin R, Kraftsik R, Boulat O, Bovet P, Conus P, Comte-Krieger E, Polari A, Steullet P, Preisig M, Teichmann T, Cuenod M, & Do K Q , Genetic dysregulation of glutathione synthesis predicts alteration of plasma thiol redox status in schizophrenia. Antioxidants & Redox Signaling 2010 Oct 30. [Epub ahead of print]

Berk M, Conus P, Kapczinski F, Andreazza AC, Yücel M, Wood SJ, Pantelis C, Malhi GS, Dodd S, Bechdolf A, Amminger PG, Hickie IB, McGorry PD. From neuroprogression to neuroprotection: Implications for clinical care. Medical Journal of Australia 2010, 193(4):36-40

Berk M, Munib A, Dean O, Malhi G, Kohlmann K, Schapkaitz I, Jeavons S,  Katz F, Andreson-Hunt M, Conus P, Hanna B, Omar R, Cololov D, Bush A. The use of qualitative research tools in drug discovery: Data and methods from a trial of N-Acetyl Cystein in schizophrenia. Journal of Clinical Psychiatry 2010, Sep 21[Epub ahead of print]

Lambert M, Conus P, Cotton S, Robinson J, McGorry PD, Schimmelmann BG. Prevalence, predictors, and consequences of persistent antipsychotic medication refusal in first-episode psychosis. Journal Of Clinical  Psychopharmacology 2010, 30(5) :565-572.

Conus P. Premier épisode thymique : cas particulier de l’intervention dans la phase précoce des troubles bipolaires. Encéphale 2010 ; 36(Suppl) :1-6.

Berk M, Brnabic A, Dodd S, Kelin K, Tohen M, Malhi GS, Conus P, McGorry PD. Does Stage of Illness Impact Treatment Response in Bipolar Disorder?  Empirical Support for the Staging Model and Early Intervention. Bipolar Disorders 2011; 13(1):87-89

Macneil C. Hasty M, Conus P, Macmillan I, Evans M, Maud D, Shelton C, Hughes A, Berk M. Is diagnosis enough? Using case formulation in therapy. Acta Neuropsychiatrica

Schimmelmann BG, Conus P, Cotton S, Kupferschmid S, McGorry PD, Lambert M. Cannabis use disorder and age at onset of psychosis – A study in first episode patients. Schizophrenia Research  2011;129(1):52-56.

Macneil C, Hasty MK, Berk M, Henry L, Evans M, Redlich C, Daglas R, McGorry PD, Conus P. Psychological needs of adolescents in the early phase of bipolar disorders: Implications for early intervention. Early Intervention in Psychiatry 2011; 5(2):100-7.

Bonsack C, Gibellini S, Montagrin Y, Favrod J, Besson J, Bovet P, Conus P. Motivational intervention to reduce cannabis in young people with psychosis: a randomised controlled trial. Psychotherapy and Psychosomatics 2011; 80(5):287-97

Schimmelmann BG, Conus P, Cotton S, Kupferschmid S, McGorry PD, Lambert M. Prevalence and impact of cannabis use disorder in adolescents with early onset first episode psychosis. European Journal of Psychiatry 2011 May 24 [Epub ahead of print]

Favrod J, Crespi S, Faust JM, Polari A, Bonsack C, Conus P. A psycho-education tool for patients with first-episode psychosis. Acta Neuropsychiatrica 2011; 23(2):75-77.